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- Road of the dead 2 alpha mutant movie#
- Road of the dead 2 alpha mutant mod#
- Road of the dead 2 alpha mutant plus#
revealed an underdiagnosis of both α 0-thalassaemia trait and α-thalassaemia hydrops foetalis. For example, a retrospective study of obstetric records in the U.K. The reason for discussing this here is therefore not because these diseases are rare, rather that they may be rarely considered by physicians outside of the regions where thalassaemia commonly occurs. In areas where the carrier state is common, two clinically important diseases (HbH disease and Hb Bart's hydrops foetalis) occur in compound heterozygotes and homozygotes. This is because carriers of α thalassaemia are thought to be at a selective advantage in areas where falciparum malaria is or has been endemic. Carriers of α thalassaemia are found at polymorphic frequencies (>1%) in all tropical and subtropical populations that have been studied and, in some areas, the carrier state has almost gone to fixation. On the contrary, it is one of the most common human genetic abnormalities known. Why should α thalassaemia be considered in a forum dedicated to rare diseases? It is certainly not a rare genetic trait. Most pregnancies in which the foetus is known to have the haemoglobin Bart's hydrops foetalis syndrome are terminated due to the increased risk of both maternal and foetal morbidity. HbH patients may require intermittent transfusion therapy especially during intercurrent illness. Carriers of alpha +- or alpha 0-thalassaemia alleles generally do not need treatment. Genetic counselling is offered to couples at risk for HbH disease or haemoglobin Bart's Hydrops Foetalis Syndrome. The mode of transmission of alpha thalassaemia is autosomal recessive. The distinguishing features of the haemoglobin Bart's hydrops foetalis syndrome are the presence of Hb Bart's and the total absence of HbF. The type of mutation influences the clinical severity of HbH disease. The predominant features in HbH disease are anaemia with variable amounts of HbH (0.8-40%). Molecular analysis is usually required to confirm the haematological observations (especially in silent alpha-thalassaemia and alpha-thalassaemia trait). All affected individuals have a variable degree of anaemia (low Hb), reduced mean corpuscular haemoglobin (MCH/pg), reduced mean corpuscular volume (MCV/fl) and a normal/slightly reduced level of HbA 2. The normal complement of four functional alpha-globin genes may be decreased by 1, 2, 3 or all 4 copies of the genes, explaining the clinical variation and increasing severity of the disease. Alpha thalassaemia most frequently results from deletion of one or both alpha genes from the chromosome and can be classified according to its genotype/phenotype correlation. Hb Bart's hydrops foetalis is a lethal form in which no alpha-globin is synthesized. Compound heterozygotes and some homozygotes have a moderate to severe form of alpha thalassaemia called HbH disease. During the last few decades the incidence of alpha thalassaemia in North-European countries and Northern America has increased because of demographic changes. It is probably the most common monogenic gene disorder in the world and is especially frequent in Mediterranean countries, South-East Asia, Africa, the Middle East and in the Indian subcontinent. More inspiration from other sources (sites, bloggers, etc.Alpha-thalassaemia is inherited as an autosomal recessive disorder characterised by a microcytic hypochromic anaemia, and a clinical phenotype varying from almost asymptomatic to a lethal haemolytic anaemia. Thunder Road: The Ram and Wreck Survival Game Moongha Invaders: Mad Scientists and Atomic Monsters Attack the Earth! Teenage Mutant Ninja Turtles: After the Bomb
Road of the dead 2 alpha mutant mod#
*No formal product release, now relegated to the interwebsĭino D-Day (Dinosaurs & Nazi mod for Half-Life) Wildspace (abandoned TSR Spelljammer VHS game)*
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Thundarr the Barbarian (links to a GWW post with several links)įRANCHISES (Three or more categories, most with multiple movies) Scatter, Adapt, and Remember: How Humans Will Survive a Mass ExtinctionĪdventures of Buckaroo Banzai Across the 8th Dimension, TheĬaptain Power and the Soldiers of the Future
Road of the dead 2 alpha mutant movie#
World War Z (link goes to book, but page includes movie link)
Road of the dead 2 alpha mutant plus#
War of the Worlds Plus Blood, Guts, and Zombies Here's some additional thoughts on what gets included in Appendix G. I tried to choose the source that had the most, best, or central jump-point for finding more info. I can't say I've read/seen all of those listed, but it's at least a good place to start with the genre overall. This list is a work in progress, and by no means exhaustive. In the spirit of Gary Gygax's Appendix N, list of inspiration, here's a few sources for inspiration in the Gamma strain.